22. Michele Ganeless

President, Comedy Central

Helming the net with co-pres Doug Herzog, Ganeless is taking Comedy Central to new heights—whether hosting comedy fests on Twitter, greenlighting shows from the always-offensive, always-funny roasters Anthony Jeselnik and Amy Schumer or continuing to churn out eps of comedy gold—and Emmy wins—from staples like “The Daily Show” and “The Colbert Report.” Moreover, Ganeless can spot up-and-comers and displays the courage to take risks. So how does she manage it all? Her best trick for keeping that work-life balance is to “choose your boss wisely.”